Moments after Neo eats the red pill in “The Matrix,” he touches a liquefied mirror that takes over his skin, penetrating the innards of his body with computer code. When I first learned about the controversial new digital drug Abilify MyCite, I thought of this famous scene and wondered what kinds of people were being remade through this new biotechnology.

Otsuka Pharmaceuticals and Proteus Digital Health won Food and Drug Administration approval to sell Abilify MyCite in late 2017. This drug contains a digital sensor embedded within the powerful antipsychotic drug Abilify, the brand name for aripiprazole, which is used to treat schizophrenia, bipolar disorder and major depressive disorder. The goal of the digital sensor is for doctors to monitor their patients’ intake of Abilify MyCite remotely and ensure that the patient is adhering to the correct drug dose and timing.

Pills with embedded sensors mark a new era in digital health and, I believe, herald the arrival of a new kind of digital cyborg identity, which sociologist Deborah Lupton defines as “the body that is enhanced, augmented or in other ways configured by its use of digital media technologies.” Drugs are cybernetic technologies in that we absorb pharmaceuticals through metabolic processes that biochemically recode our brains and bodies.

The figure of the cyborg helps us recognize the potential of digital health technologies for enhancing human health, while at the same time critique how the practices of digital health can work to coerce, marginalize or transform individual people and entire social groups. In my view, having pills that connect us to our doctor and pharmaceutical companies via an app is dehumanizing and reduces patients’ psychic lives to a digital readout.

The Ethics of a Digital Pill

AbilifyMyCite

The sensor, made up of copper, magnesium, and silicon, functions like a battery by releasing an electric signal when it has reached the acid in your stomach. The signal sends information about the date and time you took the pill, blood pressure, temperature and level of activity to an adhesive patch worn on the skin. The patch relays this data to your smartphone app, into which users can add their self-reported mental health data about how they are feeling. Users consent to allow their doctor and up to four other caretakers to view their digital pill data, which resides in a cloud-based system.

As a sociologist, I am concerned about the formation of new pharmaceutical persons who are digitally enhanced to be compliant with the profit motives of corporations and the directives of health providers and drug companies. While all sorts of technologies monitor patients’ bodies, this is the first pharmaceutical to do so. The fact that the drug is Abilify, which is prescribed to people who experience serious mental distress, should raise many ethical red flags.

These concerns are especially relevant because the patent for the original Abilify drug expired in 2016, and this new drug technology represents a potentially lucrative new product in the global pharmaceutical armory. Based on my research on the corporate development of new drug combinations for metabolic syndrome—a constellation of major risk factors for heart disease, stroke, and diabetes—I think that the new digital version of Abilify represents what I call a “killer application” for mental illness.

Killer apps are essentially about profiting from the hottest new technology; their effectiveness for health is determined not in the clinic but in the marketplace. My concern is that as a popular killer app, the company will be motivated to profit from the technology as much as possible, regardless of whether the drug actually improves health.

To sell their drugs as killer applications, corporations create a rhetoric about digital health as progressive, clinically effective and safe. The Abilify MyCite promotional video portrays the drug as a revolutionary method of doctor-patient communication that combines both objective and self-reported data. I believe this promissory rhetoric must be challenged in light of corporate ideologies that offer technological fixes for ensuring that patients take pharmaceuticals, or drug adherence, which is fundamentally a social and not a medical problem.

 

If your medicine had a chip embedded in it—that tracked and reported when you took it—would you be more likely to take it as the doctor prescribed? (haryigit/shutterstock)

More Human Contact, Not Less

Nonadherence is described in medical literature as leading to poor health outcomes, increased mortality, invalidation of clinical trials and increased health costs. But, adherence is not simply a matter of taking a medication or not.

Having the ability or desire to adhere to a medical plan also involves cultivating adequate levels of social and financial support, robust human communication between the doctor and patient, and sound health care beliefs. The digital pill offers the new possibility of distant and mediated interaction between doctors and patients, thereby decreasing the need for face-to-face communication. This means that patients will have fewer opportunities to tell their doctor why they do not adhere to a drug treatment plan.

Research exploring why patients deviate from treatment plans shows that many feel they have a lack of control over their medical lives and therefore reject elements of treatment as an act of defiance. Patients often express that they have negative experiences with drug dosages and side effects but lack sufficient means of communicating with their doctor to resolve this problem.

Will Abilify MyCite really solve these problems? I seriously doubt it given the lack of medical evidence that digital pills actually increase adherence to drug regimens or that they can be used to change drug doses—a remarkable fact that is printed directly on the drug information insert in plain language.

As a society, we should be moving away from a technologically centered framework for treating mental health and toward one in which patients’ interests and agency are positioned at the center of care. This requires a more critical analysis of how the global pharmaceutical industry has taken over mental health care and what kinds of cyborg-like people they are trying to make through their products.

The ConversationThis article was written in full collaboration with Sophia Mara Ptacek.

Anthony Ryan Hatch is an associate professor of science in society at Wesleyan University in Middletown. This article was originally published on The Conversation

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